The first clinical study of a low-cost, hand-held jaundice detector invented by Rice University students was very promising in a clinical trial that was conducted on 68 patients at Queen Elizabeth Central Hospital in Blantyre, Malawi. The results will appear this week in the Early Edition of the Proceedings of the National Academy of Sciences.
Jaundice, which is caused by the buildup of bilirubin in the bloodstream, affects about 60 percent of newborns and can cause severe, untreatable brain damage or death if it is untreated. Standard jaundice tests require multiple expensive disposables and laboratory equipment like centrifuges or spectrophotometers that African hospitals typically cannot afford.
Enter BiliSpec. A low-cost, battery-powered reader designed to diagnose jaundice by immediately quantifying serum bilirubin levels from a small drop of whole blood. The study showed that BiliSpec has comparable accuracy to the more expensive laboratory tests found in high-resource settings.
Each BiliSpec test costs about 5 cents and can be performed in about two minutes right at the patient’s bedside. The price is important because it could bring testing for jaundice within reach for cash-strapped hospitals in sub-Saharan Africa.
Babies in sub-Saharan Africa are about 100 times more likely to die of jaundice than are babies in the U.S., partly because doctors diagnosing jaundice in sub-Saharan Africa have little to go on other than what their eyes tell them.
“Clinicians in sub-Saharan Africa typically diagnose jaundice by looking at a child and gauging the color of their skin or the whites of their eyes,” said study co-author Pelham Keahey, a Rice applied physics graduate student who worked alongside clinicians at Queen Elizabeth Central Hospital to gather data for the study.
“As the clinical study of BiliSpec shows, saving newborn lives in sub-Saharan Africa is achievable,” said NEST360°’s Rebecca Richards-Kortum, a Rice bioengineering professor and study co-author who has worked for more than a decade to bring effective, affordable neonatal technologies like BiliSpec to Africa. “It simply requires the right tools in the right hands at the right time.”
“The next step is a larger, two-year follow-up study of efficacy and usability that will be conducted at five hospitals in Malawi,” Keahey said. Rice won funding for the follow-up study in August from Saving Lives at Birth, a joint undertaking by the U.S. Agency for International Development (USAID), the Bill & Melinda Gates Foundation and the governments of Norway, Canada and South Korea.
BiliSpec is one component of a 17-piece neonatal package called NEST, short for Newborn Essential Solutions and Technologies, that is designed specifically for African hospitals.The study was supported by USAID.
Source: Rice University